Side effects are most severe when beginning therapy, and decrease in
frequency with time. (less than a week, but some may persist for over
six months).
important!
Foods with high fat content should be avoided; the manufacturer
advises consumers to follow a low-fat, reduced-calorie diet. Oily
stools and flatulence can be controlled by reducing the dietary fat
content to somewhere in the region of 15 grams per meal.
Absorption of fat-soluble vitamins and other fat-soluble nutrients is
inhibited by the use of orlistat. A multivitamin tablet containing
vitamins A, D, E, K, and beta-carotene should be taken once a day, at
least 2 hours before or after taking the drug.
Some claims
A 2006 animal study addressed a connection orlistat shares
with aberrant crypt foci (ACF), lesions found in the colon which are
believed to be one of the earliest precursors of colon cancer.
Despite claims that orlistat increases the risk of breast cancer
amongst clinical trial participants, there is evidence to suggest that
the introduction of specific varied preparations containing orlistat,
namely the concurrent administration of orlistat and the monoclonal
antibody trastuzumab, can actually induce cell death in tumor cells and
block their growth.
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Last update: 2008-05-09 12:47
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Revision: 1.31
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