Caution is to be exercised in prescribing ADIPEX-P® (phentermine hydrochloride) for patients with even mild hypertension.

Insulin requirements in diabetes mellitus may be altered in association with the use of ADIPEX-P® and the concomitant dietary regimen.

ADIPEX-P® may decrease the hypotensive effect of guanethidine.

The least amount feasible should be prescribed or dispensed at one time in order to minimize the possibility of overdosage.

Carcinogenesis, Mutagenesis, Impairment of Fertility:
Studies have not been performed with ADIPEX-P® (phentermine hydrochloride) to
determine the potential for carcinogenesis, mutagenesis or impairmentf fertility.

Pregnancy–Teratogenic Effects:
Pregnancy Category C. Animal reproduction studies have not been conducted with ADIPEX-P®. It is also not known whether ADIPEX-P® can cause fetal harm when
administered to a pregnant woman or can affect reproductive capacity.
ADIPEX-P® should be given to a pregnant woman only if clearly needed.

Nursing Mothers
Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

ADVERSE REACTIONS

Cardiovascular: Primary pulmonary hypertension and/or regurgitant cardiac valvular disease (see WARNINGS), palpitation, tachycardia, elevation of blood pressure.

Central Nervous System: Overstimulation, restlessness, dizziness, insomnia, euphoria, dysphoria, tremor, headache; rarely psychotic episodes at recommended doses.

Gastrointestinal: Dryness of the mouth, unpleasant taste, diarrhea, constipation, other gastrointestinal disturbances.

Allergic: Urticaria.

Endocrine: Impotence, changes in libido.

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source: Adipex-P® manufacturer - http://www.gatepharma.com/Adipex-P/adipexscript.pdf